
This hearty Cattle Drive Casserole combines savory ground beef with Southwestern flavors for a comforting meal that's become my go-to dinner solution on busy weeknights. The layers of seasoned meat, vegetables, and creamy topping create a satisfying dish that always earns rave reviews at my family table.
I first made this casserole when hosting my husband's hungry coworkers for dinner, and the empty dish told me everything I needed to know. Now it's requested whenever we have guests who appreciate hearty, unpretentious food with bold flavors.
Ingredients
- Ground beef: choose 80/20 for best flavor without excessive grease
- Green bell pepper: adds fresh crunch and color
- Yellow onions: their sweetness balances the savory elements
- Taco seasoning packets: provide consistent flavor but homemade blend works wonderfully
- Bisquick: creates a perfect tender crust that supports all the toppings
- Sour cream and mayonnaise: these create the luxurious creamy layer that makes this dish special
- Cheddar cheese: opt for block cheese you shred yourself for better melting
- Canned green chilies: provide gentle heat without overwhelming spice
- Canned diced tomatoes: add brightness and acidity
- Whole kernel corn: brings sweetness and texture contrast
- Black pepper: freshly ground makes a noticeable difference
How To Make Cattle Drive Casserole
- Prepare the base:
- Brown the ground beef thoroughly over medium high heat, breaking it into small crumbles with your spoon. Once fully cooked with no pink remaining, drain excess fat carefully. Add the diced onions and bell peppers directly to the meat, then sprinkle with taco seasoning and water. Allow this mixture to simmer gently for 10 minutes until vegetables soften and the flavors meld together.
- Create the crust:
- While the meat mixture simmers, combine Bisquick with water until it forms a soft, spreadable dough. This consistency should be somewhere between pancake batter and cookie dough. Spread this evenly across the bottom of your prepared baking dish, taking care to reach all corners. The brief 5 minute prebake ensures the crust won't become soggy under all those delicious toppings.
- Layer the fillings:
- Once your crust has its head start in the oven, begin layering your casserole. First spread the seasoned beef mixture evenly over the partially baked crust. Next distribute the drained corn and tomatoes across the meat layer. Each component should be spread evenly for consistent flavor in every bite.
- Add the creamy topping:
- In a separate bowl, create the crowning glory by combining sour cream, mayonnaise, half the shredded cheese, diced green chilies, and black pepper until smooth. This mixture should have a spreadable consistency. Carefully spread this across the casserole, then sprinkle the remaining cheese over the entire surface to create that irresistible golden topping.
- Bake to perfection:
- Bake your assembled casserole for a full 30 minutes until bubbling around the edges with a beautifully golden cheese topping. The resting period after baking is crucial allowing the layers to set properly for clean serving.

My absolute favorite part of this recipe is the contrast between the tender Bisquick crust and the creamy topping. The first time I served this at a family gathering, my father in law who typically avoids casseroles took three helpings and asked for the recipe. That moment cemented this dish as a permanent addition to our family cookbook.
Storing Leftovers
Cattle Drive Casserole keeps beautifully in the refrigerator for up to 4 days when stored in an airtight container. For best results, reheat individual portions in the microwave for 1-2 minutes until just heated through. The entire casserole can also be reheated in a 325°F oven, covered with foil for about 20 minutes. I often make a double batch specifically to have planned leftovers for busy weekday lunches.

Customization Options
This recipe welcomes adaptations based on your family's preferences. For a spicier version, add jalapeños or use hot taco seasoning. To lighten it up, substitute ground turkey for beef and use light sour cream and mayonnaise. My vegetarian daughter enjoys it with black beans and additional vegetables replacing the meat. The Bisquick crust can also be enhanced with a tablespoon of cornmeal for added texture or a sprinkle of garlic powder for depth.
Serving Suggestions
While this casserole stands alone as a complete meal, I like to serve it with simple accompaniments that complement its Southwestern flavors. A crisp green salad with cilantro lime dressing provides freshness, while sliced avocado adds creamy richness. For casual gatherings, set out bowls of additional toppings like sliced black olives, chopped green onions, and fresh cilantro so guests can customize their portions. A basket of warm tortilla chips on the side never goes amiss for scooping up any stray bits of this delicious casserole.
Frequently Asked Questions
- → Can I use ground turkey instead of beef?
Yes, ground turkey is a great substitute for beef in this casserole. It provides a lighter option while maintaining flavor when paired with the taco seasoning and vegetables.
- → Can I make this dish ahead of time?
Absolutely! Prepare the layers as directed, cover tightly, and refrigerate for up to a day. Bake as instructed when ready to serve.
- → What can I serve with this casserole?
This dish pairs well with a fresh green salad, steamed vegetables, or even tortilla chips for added crunch.
- → Can I freeze leftovers?
Yes, you can freeze leftovers. Allow the casserole to cool completely, then portion into airtight containers and freeze for up to 3 months. Reheat in the oven or microwave when ready to enjoy.
- → How can I adjust the spice level?
For a milder flavor, use half the taco seasoning and skip the green chilies. For more heat, add extra chilies or a pinch of cayenne pepper.