
Mac and Cheese Meatloaf brings together two comfort food favorites in one cozy baked casserole. With a tender meatloaf base smothered in rich barbecue sauce and a creamy mac and cheese crown, this dish is a surefire hit for family nights and potlucks alike.
I love the way this dish always gets the whole table talking. The first time I made it for a game day, everyone wanted seconds and the recipe.
Ingredients
- Lean ground beef: adds richness and a hearty base use fresh beef for the best result
- Ritz Crackers: provide a buttery binder crush them well for even texture
- Lipton onion soup mix: seasons the meatloaf with classic depth check the date to ensure full flavor
- Eggs: help hold everything together and give moisture use large eggs for best structure
- Ketchup: adds sweet tang to the glaze look for thick ketchup with no watery separation
- Barbecue sauce: creates smoky layers of flavor pick a brand you love for best taste
- Macaroni noodles: offer classic comfort cook just until al dente for best texture
- Milk: thins the cheese sauce whole milk is richest but any milk works
- Condensed cheddar cheese soup: makes the sauce extra creamy look for high-quality brands without off flavors
- Salt and pepper: balance flavors grind fresh pepper for more kick
- Garlic powder and onion powder: amp up the savoriness try to use fresh spices for maximum punch
- Shredded mozzarella and cheddar blend: melts into a bubbly crust grate cheese at home if possible for the smoothest melt
Instructions
- Preheat and Prep:
- Set your oven to 350°F 175°C and grease a 9 x 13 inch baking dish so nothing sticks and cleanup is a breeze
- Mix the Glaze:
- Stir together the ketchup and barbecue sauce in a bowl until fully blended then set aside for layering later
- Make the Meatloaf Mixture:
- Place ground beef in a large bowl and crush the Ritz Crackers finely before adding them in Sprinkle over the Lipton onion soup mix Crack in the eggs and pour in half a cup of your glaze mixture Gently but thoroughly mix everything by hand until all the ingredients look well combined Without overmixing press this mixture firmly and evenly into the prepared baking dish to form a solid base Spread the rest of the glaze over the top in a smooth layer
- Initial Bake:
- Place the meatloaf in the oven and bake it for 30 minutes This firms it up and gives the glaze time to caramelize
- Cook the Macaroni:
- While the meatloaf bakes put the macaroni noodles in a large pot of salted boiling water and stir often to prevent sticking As soon as they reach al dente texture drain immediately so they do not turn mushy
- Mix the Cheese Sauce:
- In a separate bowl whisk milk and condensed cheddar cheese soup until perfectly smooth Sprinkle in the salt pepper garlic powder and onion powder for even flavor Add the cooked macaroni and two cups of cheese then stir gently until all pieces are evenly coated
- Layer and Finish Baking:
- Carefully remove the meatloaf from the oven and pour the cheesy macaroni mixture over the top Spread it out all the way to the edges Sprinkle the remaining cheese evenly on top Return to the oven and bake for 17 to 20 minutes until the cheese melts and you see golden spots across the surface Let it sit for a few minutes so slicing is easy

The cheese topping is my absolute favorite and I often add extra just for that golden bubbly crust I still remember my nephew sneaking the crispy edges right out of the dish the first time I served this for Sunday dinner
Storage Tips
Store leftovers in an airtight container in the fridge for up to four days For longer storage wrap tightly and freeze in single servings It reheats beautifully in the oven or microwave and I sometimes make a double batch just for tasty lunches all week
Ingredient Substitutions
You can swap the beef for ground turkey or use a plant-based crumble for a vegetarian twist Ritz Crackers can be replaced with any buttery cracker or even plain breadcrumbs If you prefer different cheeses try swapping in Colby Jack or Pepper Jack for some heat
Serving Suggestions
Scoop out generous portions and pair with a crisp green salad or simple roasted broccoli For a fun twist crumble crispy fried onions or fresh herbs over the baked cheese right before serving This is also amazing served with extra barbecue sauce on the side
Cultural Background
This dish takes inspiration from classic American comfort food blending the traditional meatloaf so many families know with the creamy mac and cheese kids love It is a true crowd pleaser and a playful way to shake up your regular weeknight dinner routine

This casserole gives you classic comfort food with a fun twist. Every bite delivers a perfect mix of cheesy, savory, and smoky flavors.
Frequently Asked Questions
- → Can I use different cheeses for the topping?
Yes, feel free to substitute with your favorite cheese blends such as pepper jack, gouda, or Swiss for a unique twist.
- → Is it possible to prep this dish ahead of time?
You can assemble the components in advance and refrigerate. Bake just before serving for best texture and taste.
- → Can I use ground turkey instead of beef?
Ground turkey works well as a substitute. Be sure to adjust seasoning for flavor and moisture.
- → How do I store leftovers?
Place cooled portions in an airtight container and refrigerate for up to three days. Reheat thoroughly before serving.
- → What sides complement this dish?
Fresh green salads, roasted vegetables, or garlic bread make excellent sides alongside this casserole.