Mexican Casserole Ground Beef

Featured in: Center of the plate recipes

Savory ground beef is simmered with beans, tomatoes, onion, and taco seasoning, then layered with crushed tortilla chips and shredded cheddar cheese. Baked until bubbly, this casserole delivers a satisfying balance of textures and classic Mexican-inspired flavors. Easy to assemble, it's perfect for a family dinner or casual gathering. Serve it topped with cool sour cream and vibrant salsa to complete the dish.

A woman in an apron is preparing a meal in a sunny kitchen filled with fresh vegetables and herbs.
Updated on Sun, 08 Jun 2025 20:58:02 GMT
A Mexican casserole with tomatoes, cheese, and meat. Pin it
A Mexican casserole with tomatoes, cheese, and meat. | mrcuisto.com

This comforting Mexican casserole is what I make whenever I need a crowd-pleaser for potlucks or family dinners It is loaded with bold flavors creamy textures and plenty of oozy cheese for a dish that disappears every time

I made it for my kids’ birthday and now they ask for it at every celebration The best part is how the cheesy topping crisps up in the oven

  • Lean ground beef: Choose high quality ground beef for best flavor and less grease
  • Ranch Style beans: These add signature Tex Mex depth and make the casserole hearty Use your favorite brand
  • Tortilla chips: Go for sturdy or restaurant style chips to hold up in layers The crunch adds great texture
  • Ro tel tomatoes: These add mild heat and tang You can sub in diced tomatoes with green chilies if needed
  • Small onion: Choose a fresh firm onion Finely chopped blends in best
  • Shredded cheddar cheese: Always buy a block and shred it yourself for creamy melt and better taste
  • Taco seasoning: Pick a flavorful taco mix or make your own for total control over spice
  • Cream of chicken soup: This binds everything together for that crave worthy creamy base
  • Water: Helps blend and loosen the mixture so it is not dry
  • Sour cream and salsa: These toppings brighten things up Add at the end or let everyone add their own

When possible use fresh cheese and onions since they make a difference in quality

Step by Step Instructions

Brown the Meat:
Cook the ground beef in a large skillet over medium heat Stir occasionally and break it up as it cooks Let it go until fully browned and any juices have mostly evaporated This step develops much of the casserole’s savoriness Drain any excess fat to keep the final dish from feeling greasy
Build the Base Mixture:
To the beef add the chopped onion and cook briefly for about two minutes to soften Next stir in the Ranch Style beans Ro tel tomatoes taco seasoning cream of chicken soup and water Mix thoroughly so the soup and beans are fully incorporated Simmer over medium low heat for about five minutes to blend flavors
Layer the Casserole:
Lightly grease a nine by thirteen inch casserole dish Scatter a generous layer of crushed tortilla chips across the bottom making sure the chips are evenly spread Pour half the meat and bean mixture over chips Next add half of the shredded cheddar cheese covering the meat Repeat with another layer of the crushed chips then the remaining meat mixture followed by the rest of the cheese
Bake the Casserole:
Cover the dish tightly with foil This keeps the casserole moist and melty Bake on the center oven rack at 325 degrees for 20 to 30 minutes Remove foil for the last five minutes if you want the cheese to get golden and slightly crisp on top
Rest and Serve:
Once bubbling and hot remove from the oven Let the casserole rest uncovered for five to ten minutes This helps it set so the pieces hold their shape when sliced Top with sour cream and salsa as you serve
A Mexican casserole with tomatoes, cheese, and sour cream. Pin it
A Mexican casserole with tomatoes, cheese, and sour cream. | mrcuisto.com

This was my dad’s favorite potluck dish He loved sneaking extra cheese on top during the last five minutes of baking and I think that gooey topping made the meal memorable for all of us

Storage Tips

Store leftover Mexican casserole by letting it cool completely then covering tightly with foil or transferring to an airtight container It keeps well in the refrigerator for three to four days The chips will soften a bit but the flavors just get better Reheat portions covered in the oven or use a microwave for a quick lunch

Ingredient Substitutions

If you cannot find Ranch Style beans use canned pinto or black beans with a little extra taco spice For a chicken version swap the beef for shredded rotisserie chicken or use lean ground turkey Cream of mushroom soup works in place of chicken soup if that is what you have on hand Choose Monterey Jack instead of cheddar for a meltier finish

Serving Suggestions

Serve big squares with plenty of sour cream and salsa on top Fresh cilantro brightens each serving and avocado slices are always welcome For extra heat sprinkle pickled jalapenos before baking At family gatherings I like putting out a topping bar with lettuce diced tomatoes and sliced olives so everyone can customize

Cultural and Historical Context

This casserole is inspired by Tex Mex comfort food which blends Mexican and American favorites into tasty hearty casseroles Ranch Style beans and Ro tel are regional classics that date back generations making this dish a staple for Sunday suppers through much of the South and Southwest

A Mexican casserole with tomatoes, cheese, and jalapenos. Pin it
A Mexican casserole with tomatoes, cheese, and jalapenos. | mrcuisto.com
A Mexican casserole with tomatoes, cheese, and chips. Pin it
A Mexican casserole with tomatoes, cheese, and chips. | mrcuisto.com

Frequently Asked Questions

→ Can I substitute ground chicken or turkey for beef?

Yes, lean ground chicken or turkey can be used instead of beef while maintaining robust flavor. Adjust cooking time as needed.

→ What type of cheese works best?

Cheddar melts well and adds sharpness, but Monterey Jack, pepper jack, or a Mexican blend are great alternatives.

→ How do I keep the tortilla chips from getting soggy?

For extra crunch, add a top layer of chips just before serving or use thicker chips that hold up during baking.

→ Is this dish freezer-friendly?

The casserole can be assembled and frozen before baking. Thaw overnight, then bake as usual for best results.

→ What sides complement this casserole?

Serve with a simple green salad, guacamole, or Spanish rice for a complete meal with balanced flavors.

Mexican Casserole Ground Beef

Hearty layers of beef, beans, and cheddar baked with tortilla chips for bold Mexican-inspired flavor.

Prep Time
20 Minutes
Cook Time
30 Minutes
Total Time
50 Minutes
By: Zaho

Category: Main Dishes

Difficulty: Easy

Cuisine: Mexican-inspired

Yield: 8 Servings

Dietary: ~

Ingredients

→ Main components

01 450 g lean ground beef
02 1 can (approx. 425 g) Ranch Style beans
03 1 bag (280-340 g) tortilla chips, crushed (not all may be used as needed)
04 1 can (approx. 284 g) Ro-Tel diced tomatoes with green chilies
05 1 small onion, finely chopped
06 2 cups (200 g) shredded cheddar cheese, divided
07 1 package (about 30 g) taco seasoning
08 1 can (approx. 305 g) condensed cream of chicken soup
09 120 ml water

→ For serving

10 Sour cream, as desired
11 Salsa, as desired

Instructions

Step 01

Preheat the oven to 165°C. Lightly grease a 23 x 33 cm baking dish with oil or nonstick spray.

Step 02

In a large skillet over medium heat, brown the ground beef until no longer pink. Drain excess fat if necessary.

Step 03

Add Ranch Style beans, Ro-Tel tomatoes, chopped onion, taco seasoning, condensed cream of chicken soup, and water to the skillet. Stir well and simmer over medium-low heat for 5 minutes, ensuring all ingredients are thoroughly combined.

Step 04

Arrange a layer of crushed tortilla chips on the bottom of the prepared baking dish. Spoon half of the beef mixture over the chips, then sprinkle with half of the cheddar cheese. Repeat layers with remaining chips, beef mixture, and top with remaining cheese.

Step 05

Cover the dish with aluminium foil and bake in the preheated oven for 20–30 minutes, or until the casserole is bubbling throughout.

Step 06

Remove from the oven and allow to rest for 5–10 minutes. Serve individual portions topped with sour cream and salsa to taste.

Notes

  1. For enhanced flavour and texture, reserve extra tortilla chips to add at serving for added crunch.

Tools You'll Need

  • Large skillet
  • 23 x 33 cm (9 x 13 inch) baking dish
  • Aluminium foil
  • Mixing spoon

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains milk, wheat, and gluten from condensed soup, beans, and cheese.

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 495
  • Total Fat: 23 g
  • Total Carbohydrate: 48 g
  • Protein: 24 g