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Crock Pot Mississippi Meatloaf

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Discover the ultimate comfort food with this Crock Pot Mississippi Meatloaf recipe. Made with lean ground beef, savory seasonings, and a rich gravy, this meatloaf is perfect for family dinners. The addition of peperoncini peppers adds a unique flavor, while the slow cooking process ensures a tender and juicy result. Serve it hot with mashed potatoes or green beans for a complete meal. Leftovers can be stored in the refrigerator and reheated easily, making this a convenient and delicious option for busy weeknights.
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A woman in an apron is preparing a meal in a sunny kitchen filled with fresh vegetables and herbs.
Updated on Mon, 28 Jul 2025 01:02:27 GMT
Crock Pot Mississippi Meatloaf Pin it
Crock Pot Mississippi Meatloaf | myhomemaderecipe.com

This Crock Pot Mississippi Meatloaf brings classic comfort food to your table with almost no fuss. Juicy lean beef, savory seasonings, buttery gravy, and the surprise tang of peperoncini all blend together for a flavor-packed dish that cooks while you go about your day.

The first chilly autumn I tried this method I was amazed how tender and flavorful the meatloaf turned out. Now it is a go-to for both busy weeknights and Sunday suppers.

Ingredients

  • Milk: use 2 percent or whole milk for creaminess and moisture in the mix
  • Eggs: binding power for the perfect sliceable loaf
  • Granulated sugar: just a hint balances all the savory flavors
  • Au jus gravy mix: savory umami notes that create the base for the gravy use a quality brand for best results
  • Ranch seasoning: classic Mississippi tang look for a mix with simple ingredients
  • Panko breadcrumbs: these give the loaf lightness and soak up all the juices regular breadcrumbs work in a pinch
  • Lean ground beef: 85-90 percent lean keeps it juicy but not greasy buy the freshest you can find
  • Cold water: stretches the gravy without diluting flavor
  • Peperoncini juice: optional but it will bring subtle heat and brightness
  • Peperoncini peppers: just one or two adds pop of color and flavor but you can skip or add as preferred
  • Cornstarch: thickens the gravy into a velvety sauce
  • Water: for mixing the cornstarch

Instructions

Prepare the Crock Pot:
Line your crock pot with a large piece of foil that goes up the sides and spray it generously with nonstick spray This makes cleanup and lifting out the meatloaf much easier
Mix Wet Ingredients and Seasonings:
In a large bowl thoroughly whisk together milk eggs sugar one packet of au jus gravy mix one packet ranch seasoning and the breadcrumbs until everything is fully incorporated
Combine with Beef:
Add the fresh ground beef to your wet mix and use clean hands to gently combine Be gentle to keep the meatloaf tender and do not overwork
Shape and Place in Crock Pot:
Form your meatloaf mixture into a loose oval and nestle it gently into the foil lined crock pot Try not to pack it too tight for a nice texture
Make the Gravy Base:
In another bowl whisk together cold water peperoncini juice and the remaining au jus and ranch seasoning packets Blend well to ensure there are no lumps
Pour Over Meatloaf:
Carefully pour this seasoned liquid over the meatloaf and around the sides to help it soak up all the flavors as it cooks
Top with Peperoncini:
Add peperoncini peppers on top of the loaf even just one or two will perfume the meat and gravy with that unmistakable Mississippi kick
Slow Cook:
Cover and cook on low for five to six hours or on high for three to four hours Check with a thermometer the internal temp should reach one hundred sixty-five degrees
Lift Out Carefully:
Using two spatulas or gently lifting the sides of the foil transfer the finished meatloaf to a serving platter The foil makes this step much easier with all the gravy in the pot
Finish the Gravy:
Strain the gravy into a medium saucepan and bring to a simmer on medium heat In a small bowl whisk cornstarch and water until smooth Pour the slurry into simmering gravy whisking constantly for a minute until the sauce thickens
Serve:
Slice the warm meatloaf and ladle the rich gravy over each serving For a true Mississippi finish top with extra peppers if you like
A delicious barbecue beef sandwich with a generous amount of barbecue sauce, served on a white plate. Pin it
A delicious barbecue beef sandwich with a generous amount of barbecue sauce, served on a white plate. | myhomemaderecipe.com

My favorite part is using peperoncini both their juice and whole peppers Making this for my family always sparks laughs over who can handle the most peppers on their slice

Storage Tips

Let leftovers cool completely and store in airtight containers in the fridge safe for up to four days Meatloaf slices freeze beautifully just wrap tightly and place in a freezer bag Freeze the gravy separately to maintain its silky texture

Ingredient Substitutions

No panko No problem just use regular breadcrumbs or even a slice or two of soaked sandwich bread If you want a milder loaf swap out the peperoncini for mild pickled banana peppers or skip them altogether For extra depth try beef bone broth in place of water for the gravy

Serving Suggestions

I always serve this meatloaf with creamy mashed potatoes to soak up all that gravy Roasted carrots or green beans make a perfect side For a spicier plate add a few extra peppers to the finished slice and a sprinkle of coarse black pepper

A Bit of History

Mississippi style recipes are famous for combining ranch seasoning with gravy often using pepperoncini to bring zing and warmth Slow cooking in a crock pot is a Southern family tradition with roots in classic church suppers and Sunday family tables This meatloaf honors that spirit in every bite

A delicious meal of meat covered in a tangy sauce and topped with jalapenos and green onions. Pin it
A delicious meal of meat covered in a tangy sauce and topped with jalapenos and green onions. | myhomemaderecipe.com

This simple meatloaf will become a family favorite with its rich gravy and tangy twist. Try it just once and it may become your go-to for busy weeks and special meals alike.

Mississippi Meatloaf

This Crock Pot Mississippi Meatloaf recipe features lean ground beef, savory seasonings, and a rich gravy for a delicious meal.

Prep Time
20 Minutes
Cook Time
300 Minutes
Total Time
320 Minutes
By: Zaho

Category: Main Dishes

Difficulty: Intermediate

Cuisine: American

Yield: 6 Servings (6 servings)

Dietary: ~

Ingredients

01 1 cup milk (2% or higher).
02 2 large eggs, well beaten.
03 2 teaspoons granulated sugar.
04 2 (1 ounce) packets au jus gravy mix, divided use.
05 2 (1 ounce) packets ranch seasoning mix, divided use.
06 1 cup panko breadcrumbs (regular breadcrumbs can be used).
07 2 pounds lean ground beef (85/15 or 90/10).
08 3 cups cold water.
09 ¼ cup peperoncini juice (optional, for spice).
10 6 peperoncini peppers (optional, can use less).
11 2 tablespoons cornstarch.
12 2 tablespoons water.

Instructions

Step 01

In a 6 or 8-quart crock pot, place a large piece of foil into the bottom of the slow cooker, making sure it goes up the sides. Spray the foil with nonstick cooking spray.

Step 02

In a large bowl, whisk together the milk, eggs, sugar, 1 packet of the au jus gravy mix, 1 packet of the ranch seasoning mix, and the breadcrumbs until fully mixed.

Step 03

Add the ground beef to the bowl. Mix everything together until combined, but don’t overmix to avoid tough meatloaf. Use clean hands for best results.

Step 04

Add the meatloaf mixture to the crock pot and gently shape it into an oval.

Step 05

In another bowl, whisk together the cold water, peperoncini juice, and the remaining packets of au jus gravy mix and ranch seasoning. Mix until well combined.

Step 06

Pour this gravy over the meatloaf and around the sides.

Step 07

Place the peperoncini peppers on top of the meatloaf.

Step 08

Cook on low for 5-6 hours or high for 3-4 hours. It is done when the internal temperature of the meat reaches 165°F.

Step 09

Carefully lift out the meatloaf and place it on a serving dish. Use two spatulas to lift it out, or grab the sides of the foil, though this may be tricky with the gravy.

Step 10

Strain the gravy from the crock pot into a medium-sized sauce pot and place over medium heat.

Step 11

In a small bowl, whisk together the cornstarch and water until smooth.

Step 12

Once the gravy comes to a simmer, slowly pour in the cornstarch slurry while whisking continuously. Allow to simmer for 1 minute until thickened, then turn off the heat.

Step 13

Slice and serve the meatloaf, adding the gravy over each portion.

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 450
  • Total Fat: 28 g
  • Total Carbohydrate: 15 g
  • Protein: 32 g