01 -
Heat the oven to 375 F. Line a 9x5-inch loaf pan with parchment paper, leaving overhang on the long sides, and set it on a rimmed baking sheet.
02 -
In a large bowl, stir the breadcrumbs, milk, egg, onion, garlic, Worcestershire sauce, Italian seasoning, salt, and pepper until the crumbs are evenly moist.
03 -
Add the ground beef and pork. Mix gently with your hands just until combined, taking care not to overwork the mixture.
04 -
Press half of the meat mixture into the loaf pan. Make a deep trench down the center and add the mozzarella, leaving at least 1 inch of meat mixture around the edges.
05 -
Top with the remaining meat mixture and press firmly around the edges to seal. Smooth the top and patch any cracks.
06 -
Stir the ketchup, brown sugar, mustard, and vinegar together. Brush half over the loaf and bake for 55-65 minutes, brushing with more glaze halfway through, until the center reaches 160 F.
07 -
Let the meatloaf rest in the pan for 10-15 minutes. Lift it out with the parchment, slice with a sharp knife, and serve warm.